The Chemical Structure of SS-31 Research Peptide: Sequence, Molecular Formula, and Molecular Weight Explained
Research Notice: This article covers research on SS-31 research peptide and MOTS-C research peptide — available from Palmetto Peptides for laboratory use only.
Research Disclaimer: SS-31 is sold by Palmetto Peptides strictly as a research compound for in vitro and laboratory use only. It is not intended for human or veterinary consumption, administration, or therapeutic use.
SS-31 is a tetrapeptide research compound with the sequence D-Arg-Dmt-Lys-Phe-NH2, molecular formula C32H49N9O5, and molecular weight approximately 639.80 g/mol. Researchers can order SS-31 research peptide from Palmetto Peptides with full lot-specific COA documentation for mitochondrial laboratory studies.
The SS-31 Amino Acid Sequence, Position by Position
Position 1: D-Arginine (D-Arg)
The D-form of arginine contributes a positive charge at physiological pH via its guanidinium side chain. The D-configuration provides resistance to proteolytic degradation in cell-based assay work — a practical advantage over standard L-peptides.
Position 2: 2',6'-Dimethyltyrosine (Dmt)
A synthetic non-proteinogenic amino acid derived from tyrosine with two methyl groups added to the aromatic ring. This increases lipophilicity and membrane affinity, and is central to the cardiolipin-binding behavior studied in mitochondrial research. Researchers exploring related mitochondrial science may also find MOTS-C mitochondrial peptide research and mitochondrial function research relevant.
Position 3: Lysine (Lys)
Standard L-lysine contributes a positive charge at physiological pH, completing the alternating aromatic-cationic motif that defines the Szeto-Schiller family.
Position 4: Phenylalanine-NH2 (Phe-NH2)
The C-terminal amide cap eliminates the negative charge at the terminus, resulting in net charge approximately +3 at physiological pH.
Molecular Formula and Molecular Weight Reference
| Property | Value |
|---|---|
| Molecular Formula | C32H49N9O5 |
| Molecular Weight | ~639.80 g/mol |
| Net Charge (pH 7.4) | +3 |
| CAS Number | 736992-21-5 |
| Also Known As | Elamipretide, MTP-131, Bendavia |
Why This Formula Matters in Laboratory Research
The formula C32H49N9O5 is the foundation for mass spectrometry identity verification. The nitrogen-rich composition (9 nitrogen atoms) reflects the multiple guanidinium and amino groups driving the positive charge. For additional context: NAD+ research peptide science and cellular health research. Order SS-31 research peptide here.
Frequently Asked Questions
What is the amino acid sequence of SS-31?
D-Arg-Dmt-Lys-Phe-NH2, where Dmt is 2',6'-dimethyltyrosine.
What is the molecular formula of SS-31?
C32H49N9O5, molecular weight approximately 639.80 g/mol.
Is SS-31 approved for human use?
No. SS-31 has not received FDA approval. It is available exclusively as a research compound for qualified laboratory settings.
See Also: SS-31 Research Peptide: Complete Guide