The Chemical Structure of SS-31 Research Peptide: Sequence, Molecular Formula, and Molecular Weight Explained
Research Notice: This article covers research on SS-31 research peptide and MOTS-C research peptide — available from Palmetto Peptides for laboratory use only.
Research Use Only Disclaimer: All peptides listed on this page are sold exclusively for in vitro and legitimate laboratory research purposes. They are not intended for human consumption, veterinary use, or any clinical application. The information in this article is for scientific and educational reference only and does not constitute medical advice. All research use must comply with applicable federal, state, and institutional regulations. Palmetto Peptides complies fully with all applicable FDA guidelines.
Research Disclaimer: SS-31 is sold by Palmetto Peptides strictly as a research compound for in vitro and laboratory use only. It is not intended for human or veterinary consumption, administration, or therapeutic use.
For a complete overview of this research area, see the Complete Guide to SS-31 (Elamipretide) Research Peptide from Palmetto Peptides.
SS-31 is a tetrapeptide research compound with the sequence D-Arg-Dmt-Lys-Phe-NH2, molecular formula C32H49N9O5, and molecular weight approximately 639.80 g/mol. Researchers can order SS-31 research peptide from Palmetto Peptides with full lot-specific COA documentation for mitochondrial laboratory studies.
Last Updated: April 21, 2026 | Reading Time: Approximately 2 minutes | Author: Palmetto Peptides Research Team
Quick Answer
SS-31 is a tetrapeptide research compound with the sequence D-Arg-Dmt-Lys-Phe-NH2, molecular formula C32H49N9O5, and molecular weight approximately 639.80 g/mol. Researchers can order SS-31 research peptide from Palmetto Peptides with full lot-specific COA documentation for mitochondrial laboratory studies.
The SS-31 Amino Acid Sequence, Position by Position
Position 1: D-Arginine (D-Arg)
The D-form of arginine contributes a positive charge at physiological pH via its guanidinium side chain. The D-configuration provides resistance to proteolytic degradation in cell-based assay work — a practical advantage over standard L-peptides.
Position 2: 2',6'-Dimethyltyrosine (Dmt)
A synthetic non-proteinogenic amino acid derived from tyrosine with two methyl groups added to the aromatic ring. This increases lipophilicity and membrane affinity, and is central to the cardiolipin-binding behavior studied in mitochondrial research. Researchers exploring related mitochondrial science may also find MOTS-C mitochondrial peptide research and mitochondrial function research relevant.
Researchers seeking a broader review can consult the Complete Guide to SS-31 (Elamipretide) Research Peptide, which covers the full research landscape in detail.
Position 3: Lysine (Lys)
Standard L-lysine contributes a positive charge at physiological pH, completing the alternating aromatic-cationic motif that defines the Szeto-Schiller family.
Position 4: Phenylalanine-NH2 (Phe-NH2)
The C-terminal amide cap eliminates the negative charge at the terminus, resulting in net charge approximately +3 at physiological pH.
Molecular Formula and Molecular Weight Reference
| Property | Value |
|---|---|
| Molecular Formula | C32H49N9O5 |
| Molecular Weight | ~639.80 g/mol |
| Net Charge (pH 7.4) | +3 |
| CAS Number | 736992-21-5 |
| Also Known As | Elamipretide, MTP-131, Bendavia |
Why This Formula Matters in Laboratory Research
The formula C32H49N9O5 is the foundation for mass spectrometry identity verification. The nitrogen-rich composition (9 nitrogen atoms) reflects the multiple guanidinium and amino groups driving the positive charge. For additional context: NAD+ research peptide science and cellular health research. Order SS-31 research peptide here.
Frequently Asked Questions
What is the amino acid sequence of SS-31?
D-Arg-Dmt-Lys-Phe-NH2, where Dmt is 2',6'-dimethyltyrosine.
What is the molecular formula of SS-31?
C32H49N9O5, molecular weight approximately 639.80 g/mol.
Is SS-31 approved for human use?
No. SS-31 has not received FDA approval. It is available exclusively as a research compound for qualified laboratory settings.
See Also: SS-31 Research Peptide: Complete Guide